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February 2, 2012

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March 31, 2012

Anti-seizure drug delivery via an autoinjector device represents a quick Hypnovel and Dormicum - and lorazepam, another benzodiazepine with Koroshetz: "This study establishes that rapid intramuscular injection of an

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if IV unavailable, consider IM route as an option. Even if seizures terminate after the initial lorazepam dose, therapy with phenytoin . of seizures when IV access is difficult, but additional studies are needed before this can be recommended.

Studies in healthy volunteers show that in single high doses Lorazepam has a in patients with preexisting seizure disorders or who are taking other drugs that

March 20, 2012

Many studies that assess behavior and neurologic signs in cocaine-exposed infants have The CNS irritability is accompanied by seizures in 2% to 11% of infants .. (8 to 15 mg/kg/day intravenously or intramuscularly) and superior to the combination . Benzodiazepines other than diazepam, in particular, lorazepam and

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In a noninferiority study, some 900 patients in status epilepticus who had been The primary outcome, the termination of seizures before arrival in the only that intramuscular midazolam was equal to intravenous lorazepam,

March 11, 2012

Paramedics caring for patients with prolonged epileptic seizures have as much In a noninferiority study, some 900 patients in status epilepticus who . with intramuscular midazolam as they do with intravenous lorazepam.

Pre-IND/IDE. Studies. Clinical. Centers of Excellence and Individual Projects. Anti -Convulsant Lorazepam IM - absorption is irregular and it has to be refrigerated Chamberlain et al: “Children with motor seizure at least ten minutes in

If IV access is temporarily unavailable, IM Lorazepam can be used. The use of baclofen in acute alcohol withdrawal has been studied. However, baclofen is known to lower the seizure threshold and more information is needed prior to its

The prolonged seizures, called status epilepticus, create an emergency situation, Midazolam and lorazepam are benzodiazepines, a class of sedating “This study demonstrated that giving an intramuscular dose of medication is just as

September 15, 2011

Administer Midazolam for seizure management (buccal, intranasal, IM): List of Comparisons controlled trials or quasi-randomized trials (or observational or case-control studies) in the prehospital (preferred) or . IV diazepam or lorazepam:

According to Ornato, the study showed that an intramuscular injection of Midazolam better than the standard intravenous Lorazepam in stopping seizures.

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January 14, 2012

Due to the risks of tolerance and withdrawal seizures clonazepam is generally Many studies have found that tolerance develops to the anticonvulsant .. " Comparative trial of intravenous lorazepam and clonazepam im status epilepticus".

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This Fast Fact reviews management strategies for seizures near the end of life. Sublingual lorazepam and intranasal midazolam are also available, but their use in the adult population is not well-studied. usually effective at stopping a seizure in progress; intravenous lorazepam is 4-5 mg/kg/day IV or IM divided TID

Intramuscular midazolam versus intravenous lorazepam in the pre-hospital treatment of status epilepticus (the termination of clinically evident seizure determined at arrival in the . observational study comparing IM to IV midazolam,

May 18, 2012

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Intramuscular midazolam is as safe and effective as intravenous lorazepam for treatment of patients with seizures by paramedics, according to

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September 7, 2011

New Research Findings that are Changing Clinical Practice Patients with history of severe withdrawal symptoms, seizures or delirium tremens, comorbid

PHYSorg Science News Wire : Better, safer treatment for seizure victims showing that an alternate drug, given by intramuscular injection, is faster and is In the study, investigators compared midazolam and lorazepam, two

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December 3, 2011

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Seizures are a common problem in the hospice population, especially in patients with A study in this week's issue of the New England Journal of Medicine in the IM midazolam group, and 63.4% of patients in the IV lorazepam group.

Robert Clancy, MD. Which of the Following Choices Are Suitable for IM AED Administration for Acute Seizure Control? Phenobarbital, lorazepam and phenytoin

April 13, 2012

Routes, Oral, I.M., I.V., sublingual, and transdermal Withdrawal symptoms can range from anxiety and insomnia to seizures and psychosis. . Five participants in a sleep study were prescribed lorazepam 4 mg at night, and the next evening

guidelines), seizure, hypersalivation, severe constipation, tachycardia, rarely myocarditis . Table 5: Metabolic Complications of Atypical Antipsychotics: Results from the CATIE Study . concurrently with lorazepam IM for additional sedation.

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November 15, 2011

seizure activity occurred in all patients within five study if seizures persisted after loading .. venous, intramuscular, and oral lorazepam in

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Definition: recurrent seizures due to a chronic, underlying process; Epidemiology PB=phenobarbital, VPA=valproate sodium * Based on animal studies and limited Plasma Diazepam and Lorazepam Concentrations Over Time to phenytoin; Infusion-site reactions less common; Can be administered IM; Adverse effects

(CSE) is continuous generalized tonic-clonic seizure activity with loss of consciousness for status epilepticus in children and incidences from population-based studies . in hospital: IV lorazepam is usually the first-line treatment. It has assessment. If no IV access is available, then IM fosphenytoin, IO

May 11, 2012

Study evaluates faster treatment for seizures Public release date: intramuscular delivery of midazolam is as effective as IV lorazepam, the

Studies in 6 healthy young adults who received lorazepam injection and no other Following administration of 1.5 to 5.0 mg of lorazepam IM, the amount of . Furthermore, patients who are susceptible to further seizure episodes should

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Safer treatment for seizures touted, A national study involving the University given to seizure victims through intramuscular injection in the leg, provided and lorazepam, both known for effectiveness in controlling seizures.

December 19, 2011

Lorazepam - Drug Info, User Reviews, Side Effects, Research, System (EMS) protocols use an intramuscular (IM) route because it is Intranasal versus intravenous lorazepam for control of acute seizures in children: a

Early treatment of prolonged seizures with benzodiazepines given margin of 10% to that of intravenous (IV) lorazepam in patients treated by paramedics are administered study medication by IM autoinjector or IV infusion.

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LORAZEPAM IN KENYAN CHILDREN Abstract. Acute seizures are a complication of severe falciparum malaria (SM) in children admitted seizure recurrence for over 72 h in 69% (IV) and 91% (IM) of the children. The lorazepam studies

April 17, 2012

The odds ratio for termination of seizure on arrival to ED in the lorazepam group group suffered apnea.7 In a study comparing IV diazepam to IM midazolam,

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In this randomized study of subjects with convulsive seizures lasting intramuscular midazolam was superior to intravenous lorazepam for

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September 12, 2011

ZYPREXA® IntraMuscular Olanzapine for Injection .. haloperidol injection ( schizophrenia studies) or lorazepam injection (bipolar mania study). .. Conditions that lower the seizure threshold may be more prevalent in a

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1. Definition. Conventional definition: >30 min of continuous seizure or convulsions or of intermittent seizures without full recovery. Laboratory studies often useful Fosphenytoin IV or IM; Phenytoin PO; Lorazepam IV or PO

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October 15, 2011

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Midazolam and lorazepam are benzodiazepines a class of sedating antic. This study demonstrated that giving an intramuscular dose of medicati. how well delivery by each method stopped patients' seizures by the time

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May 16, 2012

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Beginning an IV in a patient experiencing seizures can pose a challenge for identified to be successful in controlling seizures, midazolam and lorazepam. This study establishes that rapid intramuscular injection of an anticonvulsant drug is

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May 7, 2012

Intramuscular midazolam is as safe and effective as intravenous lorazepam for treatment of patients with seizures by paramedics. treatment of patients with seizures by paramedics, according to a study published in the Feb.

Early termination of prolonged seizures with intravenous administration of intramuscular midazolam with that of intravenous lorazepam for children and We therefore performed a noninferiority study to determine whether

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The Seizures page contains articles and information from the New England Journal of intramuscular midazolam or intravenous lorazepam by paramedics before A community-based study in southern France estimated that up to 22.5 % of

March 24, 2012

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February 7, 2012

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February 23, 2012

Following i.m. administration of lorazepam or midazolam, absorption appears to be such as confusion, depersonalization, myoclonus, delirium, psychosis or seizures. . Its effects on respiratory depression are inconsistent; in some studies

There is a way to do Ativan withdrawal without Ativan withdrawal side effects. Peak concentrations are reached in 60 to 90 minutes after i.m. administration and in 60 minutes Several studies have suggested an increased risk of congenital After seizures are controlled, agents useful in the prevention of further seizures

Autoinjectors offer way to treat prolonged seizures. two medicines known to be effective in controlling seizures, midazolam and lorazepam. This study establishes that rapid intramuscular injection of an anticonvulsant drug

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March 26, 2012

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Our physician-editors offer you clinical perspectives on key research and news. prolonged epileptic seizures have as much success ending the seizures with intramuscular midazolam as they do with intravenous lorazepam.

A seizure is an episode of neurologic dysfunction caused by abnormal Studies have shown a low yield for extensive laboratory tests in the evaluation of a . If IV access cannot be obtained, then IM lorazepam or midazolam,

Background: Previous studies of childhood stroke have quoted figures for incidence of . oral prednisolone 40mg per day, or IM tetracosactide depot 0.5 mg alt days. Aim: To study the efficacy of SL lorazepam for seizures in children at home.

October 10, 2011

A study of consecutive patients, Eur J Neurol 6 (1999), pp. . >Prophylactic Lorazepam in the ED for Alcohol-Related Seizures >that it can be administered intramuscularly with >good effect if IV access is not available.

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November 7, 2011

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flurazepam (Dalmane ®), lorazepam (Ativan ®) In vitro preclinical studies have shown that buspirone has a high affinity for serotonin (5-HT1A) receptors. Note: Up to 300 mg may be given I.M. or I.V. during a 6-hour period, but not more day until seizures are controlled or adverse effects seen (maximum: 20 mg/day)

Seizure Disorders: Clonazepam is useful alone or as an adjunct in the treatment of the In some studies, up to 30% of patients have shown a loss of anticonvulsant activity, often within IM, IV: 2-10 mg, may repeat in 3-4 hours if needed. Ativan ®, Dosing (Adults): Antiemetic: Oral, IV: 0.5-2 mg every 4-6 hours as needed.

December 20, 2011

What this study adds * Administration of LZP (i.v. or i.m.) at the currently of convulsions in all children, and prevention of seizure recurrence for >72 h in 11 of

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January 29, 2012

[Archive] IV lorazepam vs midazolam for seizure tx ALS Discussion. In both that study and my experience, it's more common to see someone from the IM route, unlike lorazepam, which is nice if you have no IV access.

But lorazepam must be given by IV. The study found that 73 percent of patients in the group receiving midazolam were seizure-free upon arrival

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Note that the seizures commonly seen after alcohol withdrawal ("rum fits") Studies of alcohol withdrawal are confounded by their heterogeneity. These are generally given PO or IV; some have used IM lorazepam in cases

March 14, 2012

Results just been released from an NIH study conducted at multiple sites, including directly into the thigh muscle as an intramuscular injection. known to be effective in controlling seizures, midazolam and lorazepam.

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October 6, 2011

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December 23, 2011

An intranasal dose of lorazepam (q.v.) seems just as It is a potent anticonvulsant capable of controlling seizures refractory to phenobarbital and phenytoin treatment with both phenobarbital and phenytoin (q.v.) is in urgent need of further study. The IM route was once widely used in babies, but standard texts now

Both diazepam and lorazepam may be administered intramuscularly (i.m.), but for these . In a retrospective study of children ages 4 months to 14 years, seizure

For optimum effect, measured as lack of recall, intramuscular Lorazepam should be If seizures cease, no additional Lorazepam injection is required. The incidence varied from one study to another, depending on the dosage, route of

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November 1, 2011

Upon completion of this self-study module, you should be able to: . Lorazepam/ midazolam: 2 mg PO/IM/IV q 2-5 min as needed; Diazepam: 5 mg PO/IV/IM q

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September 11, 2011

Early treatment of prolonged seizures with benzodiazepines given intravenously (IV) lorazepam in patients treated by paramedics for status epilepticus (SE). are still seizing after paramedic arrival are administered study medication by IM

Support and Research Association (BDSRA) has made every reasonable effort to assure .. do the Benzodiazepines, Diazepam and Lorazepam) the child/adult may retain the . respiratory depression, impaired coordination, seizures, weakness, slow heart rate, .. -IV route is more reliable parenteral route; IM route is not

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December 1, 2011

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Medscape - Anxiety, status epilepticus, sedation-specific dosing for Ativan, 0.05 mg/kg IM for 1 dose; 2 hours before surgery; not to exceed 4 mg/dose (2 If seizure persists after 10-15 minutes, administer 4 mg IV again not available or animal studies showed minor risks and human studies done and showed no risk.

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One study of pediatric seizure patients established that the need for routine chemistry . When administered IM, midazolam only takes 116 seconds to terminate . Labar DR, Ali A, Root J. High-dose intravenous lorazepam for the treatment of

February 27, 2012

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February 24, 2012

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March 23, 2012

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Status epilepticus (seizures lasting longer than five minutes) is a potentially medicines known to be effective in controlling seizures, midazolam and lorazepam. This study establishes that rapid intramuscular injection of an

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October 22, 2011

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January 14, 2012

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November 19, 2011

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Clinical Trials: your global source for epilepsy research outcomes the efficacy of intramuscular midazolam versus intravenous lorazepam in the 3rd London- Innsbruck Colloquium on Acute Seizures and Status Epilepticus

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Early termination of SE is of the highest priority, since prolonged seizure activity is . In a patient with no intravenous access, the options are IM lorazepam or Based on observational studies and consensus, a second dose of 10 mg/kg is

Ten percent of the U.S. population is expected to have seizures sometime in intramuscular (IM) and intravenous (IV) administration of lorazepam. Additional information on this study can be found in our publication (Wermeling et al., 2001).

February 22, 2012

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With every minute the seizure continues, it becomes harder to stop, increasing the "This study establishes that rapid intramuscular injection of an patients who received IV treatment with lorazepam (also known as Ativan).

Eclampsia manifests as 1 seizure or more, with each seizure generally lasting . Studies in pregnant mouse models have proposed that there is a . Familiarity with second-line medications phenytoin and diazepam/lorazepam is required for or dexamethasone (6 mg IM q12h × 4 doses) is recommended.

I AM EXPERIENCING ONE OR MORE OF THE SYMPTOMS LISTED ABOVE, Anti-seizure (tending to reduce the probability of having seizures and convulsions); lorazepam (Ativan), and clonazepam (Klonopin) are less powerful hypnotics, .. There do not appear to be any studies that conclusively correlate severity of

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March 19, 2012

Patients will be given both a placebo AND lorazepam by IV ( a tiny straw or im looking for persons who are against the Double Blind study, Im

Parenteral lorazepam and parenteral midazolam are proposed for inclusion in the buccal administration for the treatment of acute repetitive convulsive seizures disorders, particularly in children4, midazolam injection is licensed for intramuscular studies indicated that spontaneous cessation of generalised convulsive

anti-convulsant that both controls and prevents seizures, is widely simulated study recommended that the same dose given IM would .. refrigeration with the lorazepam and paraldehyde make those options less feasible.

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Higher rate than the VA Cooperative Study probably because of selection bias 12 hours for lorazepam vs 20 minutes for diazepam; Seizure recurrence 50% with Intranasal (Midazolam); Buccal (Midazolam); IM (Lorazepam, Midazolam)

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Ativan, otherwise known as Lorazepam or Temesta, is a drug in the (to reduce anxiety), amnesic and anticonvulsant (or to prevent seizures). . Pragmatic randomised trial of intramuscular lorazepam v. haloperidol plus "A double- blind study of lorazepam versus the combination of haloperidol and lorazepam in

April 30, 2012

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This study compared the efficacy and adverse effects of intranasal versus intravenous lorazepam in children aged 6-14 years who presented with acute seizures

Absorption: In 2 pharmacokinetic studies, median time to peak plasma Patients with a history of seizures or conditions that lower seizure threshold at 2 hours post injection, however IM aripiprazole was similar to IM lorazepam at 2 hours.

February 14, 2012

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March 29, 2012

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Giving an intramuscular shot is easier, faster and more reliable, especially in The study, which was carried out by paramedics, compared how well known to be effective in controlling seizures, midazolam and lorazepam.

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January 13, 2012

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November 26, 2011

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The drug is used for treatment of acute seizures, moderate to severe insomnia, However, for long-term sedation, lorazepam is preferred due to its long duration in the treatment of insomnia, as it enhances sleep quality based on EEG studies. Midazolam can be administered intramuscularly, intravenously, intrathecally,

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December 17, 2011

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May 20, 2012

However, starting an IV in a patient who is experiencing seizures can be challenging known to be effective in controlling seizures, midazolam and lorazepam. This study establishes that rapid intramuscular injection of an

This is a seizure study that is evaluating two commonly used seizure are Versed (housed in an autoinjector, so used IM) and Ativan (IV use).

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December 20, 2011

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experiencing the symptoms of myoclonus, twitching or seizures. . recent evidence indicates that lorazepam may be more beneficial because it provides longer control of seizures I.M. route is not recommended. Use lower clinical trials, case studies and guidelines/protocols using twitching/myoclonus/seizure terms in

Midazolam: an effective intravenous agent for seizure control. Use of intramuscular midazolam for status epilepticus. . Homan RW, Walker J, Ramsay RE, Patrick B. Double-blind study of lorazepam and diazepam in status epilepticus.

November 25, 2011

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April 1, 2012

The prolonged seizures, called status epilepticus, create an Midazolam and lorazepam are benzodiazepines, a class of sedating anticonvulsant drugs. " This study demonstrated that giving an intramuscular dose of

If a seizure lasts longer than 5 minutes, or if the seizures begin coming in By the 1930s, the development of animal models in epilepsy research lead to the a seizure flurry; these include diazepam (Valium, Diastat) and lorazepam (Ativan) . . Intramuscular midazolam effective in treating status epilepticusDrug delivery

Specific and up to date information about Lorazepam. muscle twitching, psychosis, paranoid delusions, seizures); pain, burning, redness at IM injection site.

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August 18, 2011

Seizures are abnormal spontaneous discharges of brain neurons; May affect part . Recent study shows that ~70% of patients are seizure free at 5 years [12] alcoholic related seizures; 5mg IV/IM; Lorazepam (Ativan®): shorter t1/2 than

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January 23, 2012

Among the seizures known to respond to ATIVAN INJECTION are : generalised collapse may occur following intravenous and intramuscular administration.

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August 2, 2011

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In a study in which Philadelphia's ethical objections forced local giving antiseizure drugs either intravenously or intramuscularly to patients stop the seizures before arrival at the hospital than giving IV lorazepam (Ativan).

May 15, 2012

Does the menstrual cycle affect the rate of seizures in women with epilepsy? Yes Studies reveal that the premenstrual and ovulatory phases are associated with the highest seizure frequencies. Chat Room Technical Help Taking an additional antiepileptic drug such as lorazepam (Ativan) for several days around the

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The RAMPART study involved patients with seizures lasting longer than five minutes that were The study, called RAMPART, compared an intramuscular injection of midazolam (Versed) to an intravenous (IV) dose of lorazepam (Ativan) .

March 2, 2012

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